Sinapic Acid Nagaland University Discovers Plant Compound for Diabetic Wound Healing

• Researchers at Nagaland University have identified Sinapic acid , a natural compound found in edible plants, as a potential treatment for diabetic wounds. The study, published in Nature Scientific Reports , shows promising results for managing diabetic foot ulcers—a major complication of diabetes.

Key Findings:

• Mechanism: Sinapic acid promotes wound healing by activating the SIRT1 pathway , which supports tissue repair, blood vessel formation, and inflammation control.

• Effectiveness: Oral administration of Sinapic acid significantly improved healing in diabetic models. A lower dose of 20 mg/kg proved more effective than a higher dose, demonstrating an inverted dose-response effect.

• Clinical Potential: The compound offers a natural and safe alternative to synthetic drugs, potentially reducing infection and amputation risks.

Significance:
This discovery could pave the way for an affordable oral therapy for diabetic wound care, particularly benefiting patients in rural and resource-limited areas .